Research
Research Overview
Our lab investigates the core mechanisms of neuronal synaptic and circuit function, focusing on activity-dependent changes in synaptic strength and circuit connectivity within key brain regions that govern memory-guided behaviours.
We aim to understand how molecular, synaptic, and circuit-level dysfunctions contribute to disease. In particular, we are interested in functionally characterising mutations commonly found in patients with neuropsychiatric disorders such as autism spectrum disorder and schizophrenia.
Approach & Techniques
Our research draws on a diverse toolkit, including:
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Mouse genetics and gene-editing technologies
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Opto- and chemogenetics, paired with intersectional genetic and viral circuit-mapping tools
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In vitro whole-cell patch-clamp electrophysiology
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in-vivo imaging
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Transcriptomics
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Rodent behavioral assays
Current Projects
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Molecular coding of hippocampal circuits by Cerebellins
Investigating how Cerebellins form and maintain inhibitory synapses, and how they contribute to inhibitory synaptic plasticity and the stability of memory. -
Cerebellins in mPFC development and memory-guided decision making
Examining the role of Cerebellins in medial prefrontal cortex (mPFC) development, and how this shapes the age-dependent evolution of memory-guided behaviors and decision-making. -
Cerebellins and dorsal raphe circuit organization
Exploring how Cerebellins help organize dorsal raphe circuits that are critical for social behaviors. -
Molecular dissection of excitatory synapses on hippocampal interneurons
Investigating the role of 5-HT3a receptors on excitatory synapses onto inhibitory interneurons in the hippocampus, with a focus on their contribution to novelty-seeking behavior. -
Mapping social reward circuitry
Charting the neural circuits that mediate social reward, as part of our broader effort to understand social networks in the brain.