We study the core mechanisms of neuronal synaptic and circuit function including activity-dependent changes in synaptic strength and circuit connectivity, in key regions of the brain that mediate -
1. Memory-guided behaviors
2. Reward-seeking behaviors.
Our goal is to probe the molecular, synaptic and neuronal circuit malfunctions that are often found in disease- we are particularly interested in the functional characterization of mutations that are commonly found in patients with neuropsychiatric disorders like autism spectrum disorders and schizophrenia.
Some of the tools and techniques we routinely use in the lab are- mouse genetics, gene editing tools including the CRISPR-Cas9 system, Opto/chemo genetics combined with intersectional genetic and circuit mapping viral tools, in-vitro whole-cell patch-clamp electrophysiology, transcriptomics, and rodent behavior.
Molecular coding of mPFC circuits by Cerebellins.
Role of mPFC Cerebellins in mediating memory-guided behaviors.
Cerebellins and their role in neuromodulation
Molecular dissection of excitatory synapses on inhibitory interneurons.
Social networks in the brain